Cotton Belt Freight Depot
The St. Louis Southwestern Railway, known by its nickname of "The Cotton Belt Route" or simply Cotton Belt, is a former US Class I railroad which operated between St. Louis, Missouri, and various points in the states of Arkansas and Texas from 1891 to 1992.
The five-story freight depot was constructed in 1911 to handle freight movement for SSW. It has been vacant since 1959.
From Wikipedia